The Neuroimaging and Modulation Lab (NIMLAB), directed by Dr.
John E. Desmond, is part of the Cognitive Neuroscience
Division of the Department
of Neurology at the Johns
Hopkins University School of Medicine.
The laboratory investigates neural correlates of cognition and behavior using neuroimaging
methods such as functional magnetic
resonance imaging (fMRI) and neuromodulation techniques such as transcranial magnetic stimulation
• The contributions of the cerebellum, and cerebro-cerebellar
circuits, to cognition. The cerebellum has traditionally been
viewed as a structure involved in motor coordination. However, neuroimaging
and patient studies have revealed unexpected cerebellar involvement
in cognitive performance beyond motor behavior. We are specifically
interested in cerebellar contributions to verbal working memory
The effects of chonic heavy alcohol consumption on cognition and
brain activation underlying cognitive function. We are also
interested in neurovascular changes caused by alcohol, as well as
changes in brain structure and functional connectivity.
aging in humans affects neural systems that are important for associative
learning and stimulus awareness. These
investigations pay special attention to neural systems important
for classical eyeblink conditioning in the cerebellum and medial
temporal lobe, as well as structures involved in attention in the
• Integration of transcranial magnetic stimulation with
functional MRI. TMS and fMRI are complementary methods, because
fMRI can reveal which regions of the brain activate during a cognitive
task, whereas TMS can assess which of those activations are necessary
for performance. We have recently developed a system for measuring
fMRI brain activation concurrently with TMS administration in the
scanner, and these methods are particularly suited for non-invasively
studying brain connectivity in humans.